Metronidazole & Fluconazole (Combination therapy for BB)

[xbb]

Hi All,

1st of all, I would like to say thank you to keepTrying09 for information you shared with everyone that solve my 20 years problem.

About a month ago I went to see a doctor after reading your forum for few months and asking for candida test and doctor insist me to do H.pyroli test and the result is negative.

I was so frustrated and went to nearby pharmacy and ask pharmacist for anti fungus medication and they only have Ketaconazole instate of fluconazole.

I took 200mg X 1 with breakfast and for the 1st and 2nd day I got headache and I went to bed early on the second day and my headache is gone and I notice my throat is very dry at 3rd day and different taste and feel very smooth in my throat and I drink a lot of water during day time. On the 4th and 5th day I notice my breath still the same and from 6th day onward I took 200mg X 2, one in the morning and one after 12 hrs after meal for the rest 9 days. After two weeks of medication and I notice my breathing is much easier due to mucus in my nose and throat.

I am very please with the result and actually it clear my pimples too. wow.....one stone kill three birds.

If anyone would like to use Ketaconazole please do read about this medication effects and symptoms especially with liver problem!

[KeepTrying09]

Hi All,

1st of all, I would like to say thank you to keepTrying09 for information you shared with everyone that solve my 20 years problem.

You're welcome

I was so frustrated and went to nearby pharmacy and ask pharmacist for anti fungus medication and they only have Ketaconazole instate of fluconazole. I took 200mg X 1 with breakfast and for the 1st and 2nd day I got headache and I went to bed early on the second day and my headache is gone and I notice my throat is very dry at 3rd day and different taste and feel very smooth in my throat and I drink a lot of water during day time. On the 4th and 5th day I notice my breath still the same and from 6th day onward I took 200mg X 2, one in the morning and one after 12 hrs after meal for the rest 9 days. After two weeks of medication and I notice my breathing is much easier due to mucus in my nose and throat.

I am very please with the result and actually it clear my pimples too. wow.....one stone kill three birds.

Hey, that's great you found some success! Congratulations.

If anyone would like to use Ketaconazole please do read about this medication effects and symptoms especially with liver problem!

Very good advice. Thank you for sharing

[KeepTrying09]

Found two really interesting studies they did on Metronidazole and it's effect on bad breath. They are two separate studies but they both researched the same thing.

First article:

Tongue Microbiota and Malodour: Effects of Metronidazole Mouthrinse on Tongue Microbiota and Breath Odour

Authors: Hartley G.1; Mckenzie C.; Greenman J.; El-Maaytah M. A.; Scully C.; Porter S.
Source: Microbial Ecology in Health and Disease, Volume 11, Number 4, 31 December 1999 , pp. 226-232(7)

Publisher: Informa Healthcare

Abstract:

Thirty-two healthy, dentate volunteers with unexplained non-systemic halitosis took part in this blind, 2-cell (metronidazole and quinine control), randomised, single rinse, crossover study. The effects of both mouthwashes on the tongue bacterial microbiota, salivary microbiota, breath odour and the odour generating potentials of subjects' saliva were measured. Metronidazole mouthwash reduced both breath odour and incubated salivary odour to a significantly greater extent (p<0.05) than did the quinine control. The odour reduction was associated with a significant reduction in the bacterial counts per unit area of tongue surface. In particular, the reductions in the strict anaerobic species (up to 1.5 log-fold) and proportions of sulphide-producing organisms, were highly significant (p<0.001), even up to 24 hours post-rinse. This study confirmed the highly selective nature of metronidazole. The concomitant reduction of both breath odour and recovery of strict anaerobes from the tongue (correlation, r2=0.776; p<0.005) supports the theory that this group of organisms are the major contributors to oral malodour production.

Language: English
Document Type: Research article
Affiliations: 1: Oral Microbiology Unit, Faculty of Applied Sciences, University of the West of England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 IQY

Second article can be viewed on google docs at:

http://docs.google.com/viewer?a=v&q=cac ... amjJqPx4cQ

[bad day]

Hi kt09. I was lucky enough to find a GP who was willing to give prescription for Flagyl and let me try it if it will cure the bb.

I took the Flagyl about 2 months ago, 250 mg 3x a day for a 5 day course. During the course, and around 3-4 days after the course, the bb was gone. But unfortunately, it came back. I just want to ask your opinion whether I can rule out Candida as my bb cause. Since it was an anti bacterial med and not an anti-Candida med that gave me temporary relief, should I assume that my bb is not due to Candida?

I also want to try out Fluconazole but I have not found a GP or specialist who is willing to give me the med. Still trying to find one.

[KeepTrying09]

I took the Flagyl about 2 months ago, 250 mg 3x a day for a 5 day course. During the course, and around 3-4 days after the course, the bb was gone. But unfortunately, it came back.

When you took the Flagyl, were you taking any probiotics or changing your diet around at all? The fact that Metronidazole was working for you during your treatment means you're on the right track, you just gotta figure out how to make the results permanent, and that usually means turning your dietary and lifestyle choices upside down.

I just want to ask your opinion whether I can rule out Candida as my bb cause. Since it was an anti bacterial med and not an anti-Candida med that gave me temporary relief, should I assume that my bb is not due to Candida?

Well, if you haven't been tested for Candida then I guess you couldn't really rule it out 100%. But if the Flagyl made your breath better instead of worse then I would only assume it's not Candida that's causing your bad breath.

I also want to try out Fluconazole but I have not found a GP or specialist who is willing to give me the med. Still trying to find one.

Good luck in your search!

[bad day]

Hi KT. Thanks for the response.

During my course on Flagyl, I took acidophilus and cranberry juice with it, and a drink with lactobacilli. But I did not make any drastic change to my diet, since I've been assuming also that my bb is not caused by yeast and that only those with yeast or fungal overgrowth need to avoid products with yeast. Although I've avoided sweets a little bit even before I took the meds. One big lifestyle change I made was to quit cigarettes (The one thing I can say positive that came out of this bb ordeal, though it did not seem to help make the bb go away).

Any additional advice you can give regarding dietary and lifestyle changes I should be taking? Thanks!

[KeepTrying09]

Any additional advice you can give regarding dietary and lifestyle changes I should be taking? Thanks!

LOL, yeah, just start eating healthy and exercise regularly. Since you don't think it's yeast that's causing your bad breath, then I don't really think a yeast free diet would be necessary (although it wouldn't hurt to try it just for a few weeks to make sure). I would just recommend what almost anyone would in regards to diet, which means cut back on heavily processed foods and opt for whole foods instead. Try to cut back on junk food and fast food too. Eat fruits and vegetables everyday, and try to supplement with multivitamins and multi minerals if you don't think you're getting enough from the foods you eat everyday. Also try introducing some natural antimicrobial foods into your diet. Should be able to google "antimicrobial foods" and come up with a lot of info. Probiotics are great. Try and take one that has multiple strains of probiotic bacteria, not just 1 or 2. One of the probiotics I took had 14 strains of probiotic bacteria combined. Exercise at least 3 times per week, and get at least 8 hours of sleep per day. Drink plenty of water to flush out your system and hydrate yourself.

It's really just all the stuff that we've all heard since we were children, yet so many of us fail to do.

[randomized]

this thread is long I only got to page 2.

I found this one drugstore.com

http://www.drugstore.com/pharmacy/drugi ... trx=1Z5007

Is this the right one? I might consider this but normally antibiotic isn't good for your body though. oh yeah forgot to mention earlier that the 750mg is very expensive and it's for the treatment of vagina infection in which i dont have a vagina. The 500mg and 250 mg are used to treat infection and they are cheaper than the 750 mg.

you said one of the probiotics you took have 14 strains? which brand is that?

[realbad]

where can i get this biozole

[KeepTrying09]

this thread is long I only got to page 2.

I found this one drugstore.com

http://www.drugstore.com/pharmacy/drugi ... trx=1Z5007

Is this the right one?

Yeah, it's the right one, although it's a bit expensive, and I believe you need a prescription to purchase from that website. I think they require that you send the prescription to them through mail or fax or something.

you said one of the probiotics you took have 14 strains? which brand is that?

The brand I take is called Nature's Way, and the one that has 14 strains of bacteria is called Primadophilus Optima.

[realbad]

hey keeptryin i emailed you about the meds...

[KeepTrying09]

Halitosisux provided a link in another thread, but I think it relates to the research studies I posted a few posts up regarding Metronidazole mouthwash. In the below video researchers found that a woman who complained of bad breath had an overgrowth of anaerobic bacteria in her mouth. In the Metronidazole mouthwash studies I posted above, they found that the participants' bad breath was eliminated due to the fact that Metronidazole targets and kills anaerobic bacteria. The link to the video is below.

http://www.youtube.com/watch?v=SUYDWxUJG7c

[mindyb]

Concerning the You Tube videp...no dr. I've been to (in US) ever offered this kind of testing. And I've been to over 10, including dentists.
Interesting.
I wish this showed her results with what she took, and if it came back.

[mindyb]

KT09-
Is there a Metroidazole Mouthwash? I think it would be fantastic, since it would target the mouth, instead of the whole body. You can't take M forever internally.
Let me know, if not, we should really work on trying to get one made as a community!
Thanks.

[KeepTrying09]

KT09-
Is there a Metroidazole Mouthwash? I think it would be fantastic, since it would target the mouth, instead of the whole body. You can't take M forever internally.
Let me know...

As far as I know there is no commercially available metronidazole mouthwash, however a quick google search turned up this information:

...The ulcerated KS lesions on his tongue and lip, causing halitosis, difficulty eating and misery. This was initially treated with metronidazole mouthwash (made by combining 300mls water, 150mls concentrated orange juice and a crushed 200mg metronidazole tablet), ketoconazole, gentian violet paint topically to the lip lesion, and multivitamins. He was provided with straws to drink through and drawing materials to distract and cheer him up. He reported feeling better straight away after good mouth care, suggesting mouth pain and hunger were a major cause of his misery. The next day, his mouth was improving and he was drinking and eating, so he was discharged, planning to return for his second dose of vincristine the following Monday.

The above is just an excerpt from the whole document that relates to the metronidazole mouthwash, however you can read the entire document by clicking on the provided link. It is about three children in Malawi with Kaposi’s sarcoma (KS) in addition to HIV infection.

According to the above, seems like the metronidazole mouthwash is not too terribly difficult to make for yourself.