For people who have candida (tested) but don't respond to Fluconazole (diflucan, biozole, etc), there may be other options. I'm not suggesting anything here, just providing information. I don't plan on using these drugs.
Itraconazole:
The drug may be given orally or intravenously. It would seem to be similar in safety and effectiveness as Diflucan but may be a more successful treatment for certain species of candida and other fungal infections as Diflucan may be more effective for other species. Unless you have a stool sample tested and a particular species of candida/yeast can be detected and tested for sensitivity to different drugs, it is a matter of trial and error with regards to which will work best for you. Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole).
voriconazole:
is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections. Voriconazole was also proven to offer similar, near-complete efficacy to fluconazole in the treatment of esophageal candidiasis.
Posaconazole:
posaconazole may be superior to other triazoles, such as fluconazole or itraconazole, in the prevention of invasive fungal infections, although it may cause more serious side effects.
When Fluconazole isn't strong enough
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm
I think the best course of action is to find a physician who specializes in infections and go from there. I see some people here who keep seeing general practitioners, ENTs, etc but don't get anywhere. How many people have been cured after having their sinus checked up by an ENT? I don't know anyone.
Why not put that energy into finding a physician who specializes in (fungal) infections, we have proof that candida can invade the esophagus and cause chronic BB as seen in the pictures provided by KT, and it is treatable.
Why not put that energy into finding a physician who specializes in (fungal) infections, we have proof that candida can invade the esophagus and cause chronic BB as seen in the pictures provided by KT, and it is treatable.
Hi Keep Trying
Hi Keeptrying,
Do you get voriconazole in thailand?
Please advice.
Harry
Do you get voriconazole in thailand?
Please advice.
Harry
Hi
Hi Keeptrying,
I am asking this to know if the drug (voriconazole) still exists in the market. I have tried fluconazole for 15 days and it did not work.
All good drugs that give us a remedy are all getting outdated or dis-continued, with some reason or other (once could be that we develop resistance to that or we find new type of species that the old drug does not clear).
Clotrimazole had tablets with a combination of probiotics few years back. Now they have discontinued that. That's a pity. Clotrimazole is the strongest anti-fungal, says some studies and research. But, we are just left with creams, oral paints and powders (no internal consumption).
Regards
Harry
I am asking this to know if the drug (voriconazole) still exists in the market. I have tried fluconazole for 15 days and it did not work.
All good drugs that give us a remedy are all getting outdated or dis-continued, with some reason or other (once could be that we develop resistance to that or we find new type of species that the old drug does not clear).
Clotrimazole had tablets with a combination of probiotics few years back. Now they have discontinued that. That's a pity. Clotrimazole is the strongest anti-fungal, says some studies and research. But, we are just left with creams, oral paints and powders (no internal consumption).
Regards
Harry
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm
Re: Hi
That explains Meowkitty being cured. That's 2 people cured by antifungals, hopefully there will be more, i have no doubt. But for those who have extreme chronic BB, a 14-day course of Fluco might not be nearly enough, i wonder how more effective an intravenous treatment is. That is why we need a top physician, someone who treats AIDs patients and other people with severe infections. Well, some people here are getting endoscopies, so we might know more soon.Harry_2K wrote:Clotrimazole is the strongest anti-fungal, says some studies and research.
Voriconazole is in the market, maybe you couln´t find it because is a new antifungal.Harry_2K wrote:I am asking this to know if the drug (voriconazole) still exists in the market. I have tried fluconazole for 15 days and it did not work.
Voriconazole is better that fluconazole because voriconazole combats the candida genres that fluconazole doesn´t do.
Voriconazol in Peru, 7 tables from pfizer cost $400
Harry_2K, which concentration of fluconazole you took?
We can´t use clotrimazole because clotrimazole is for dermical, vaginal and oral use, It can´t be absorbed by the digestive system.Harry_2K wrote:Clotrimazole had tablets with a combination of probiotics few years back. Now they have discontinued that. That's a pity. Clotrimazole is the strongest anti-fungal, says some studies and research. But, we are just left with creams, oral paints and powders (no internal consumption).
My experience with fluconazol
Here in Peru, there are several brands of fluconazol and generic fluconazol. The brands ones are generally more expensive, but in theory, are the same fluconazol.
But in my experience and the experience of a dermatologist, the generic ones are often ineffective and only some of the brand ones are truly effective.
I used and saw others using generic fluconazol with no improvement, also a brand one (Funzal twin from Pharmalab) is ineffective, but the brand Flucofas from Medrick works very well and is cheaper than others brands.
-
KeepTrying09
- Sheriff
- Posts: 463
- Joined: Sun Nov 15, 2009 3:14 pm
- Location: Thailand
Hey Guys,
Wow, there's a lot of interest in this topic I can tell. Let me try and cover everyone's questions and concerns in one post.
1.) Yes, here in Thailand itraconazole is available over the counter, as well as ketoconazole. While voriconazole is available here in Thailand, I haven't seen it in any of the pharmacies I've been to. Perhaps they only stock it in the hospitals, or maybe I just haven't noticed it in the pharmacies because I haven't been looking for it. Voriconazole is a hard core anti-fungal, and I believe if you are going to take that one, you really need to be under the care of a doctor. It is for like people who are seriously immunocompromised (i.e. Aids or cancer patients). In regards to posaconazole I have never heard about that one and I don't think it's here in Thailand yet.
2.) I totally agree that everyone should be searching for a doctor who specializes in Fungal infections. Unfortunately, there don't seem to be that many, and the ones who are might be located far away from the patient. I think there have been enough people on this forum whose doctor has dismissed them or looked at them like they were crazy when they mentioned Candida. But that doesn't mean you should give up hope. I have always promoted that people be tested for Candida if they can find a doctor who is willing.
3.) I don't know about meowkity. Perhaps the clotrimazole lotion she rubbed on her chest and neck cleared her tongue, and perhaps it didn't. The odds of that working are very low though. Clotrimazole is rarely absorbed into the bloodstream. If you see the skin chart below while you read this, it will make sense. Basically, the quote below is saying that clotrimazole is only absorbed into the skin in micrograms (mcg), not milligrams (mg). To put it clearly, it would take 1,000 micrograms to equal 1 milligram. You guys are taking 200 milligrams of Fluconazole internally. That would equal 200,000 micrograms. You can see for yourselves in the quote below, but there is nowhere near 200,000 micrograms of clotrimazole cream being absorbed into your skin. But if you don't wanna read the quote, you are basically absorbing only 1 microgram of clotrimazole or less. Needless to say, you are far better off taking the Fluconazole capsule rather than the Clotrimazole cream.
4.) To Harry_2K, if I recall correctly, you got your Fluconazole from an online pharmacy, correct? I have said many times, you cannot be certain what you order from an online pharmacy is real or not. The United States FDA found that 24 online pharmacies were selling counterfeit drugs. You can see the names of the websites that were selling fake presciptions at http://www.fda.gov/NewsEvents/Newsroom/ ... 108904.htm. Also you can see the video below about it (sorry there is a 15 second commercial for soap before the actual video.)
<embed src='http://cnettv.cnet.com/av/video/cbsnews ... r-dest.swf' FlashVars='linkUrl=http://www.cbsnews.com/video/watch/?id= ... &salign=tl' allowFullScreen='true' width='425' height='324' type='application/x-shockwave-flash' pluginspage='http://www.macromedia.com/go/getflashplayer'></embed>
5.) I'd have to disagree regarding generic brands being inferior to brand name drugs. The reason brand name drugs are so expensive is because the drug companies have to pay for all the marketing they do, not because the drug is better. The companies that make the generic drugs don't have this overhead, so they can sell the drugs at a cheaper cost. There have been many studies that show generic drugs to be just as effective as brand name drugs. I think the reason some drugs are effective for some people while not effective for others is really because not everyone responds exactly the same to the same treatment. Which leads me to.........
6.) I had a Candida infection in my esophagus. That is what caused my bad breath. But before I found that out, I went through all these things to try and cure my bad breath:
- I bought therabreath - (spent money, it did nothing)
- I bought oxyfresh - (spent money, it did nothing)
- I bought breathrx - (spent money, it did nothing)
- I bought special tongue cleaners - (spent money, it did nothing)
- I bought internal breath fresheners and chewed all kinds of gum - (spent money, it did nothing)
- I had all four of my wisdom teeth removed - (insurance covered it, it did nothing)
- I had my tonsils taken out - (insurance covered it, it did nothing)
- I was a vegetarian for 2 months - (no money lost but time wasted, it did nothing)
- I took PPIs (proton pump inhibitors) for GERD/Acid Reflux (insurance covered it, it did nothing)
- I tried charcoal capsules - (spent money, it did nothing)
- I had deep cleanings by my dentist (insurance covered half, I paid the rest, it did nothing)
- I was diagnosed with Candida, I took BioZole (I was cured)
Obviously, not all of you have bad breath caused by a Candida infection. But as you can see, I tried many different things before I found my cure. All of you will probably have to go through the same thing. It's all trail and error. I pray that some of you will be cured by antifungal medicine, because I really do think Candida infection is more common than doctors would have you believe. If you do indeed have a Candida infection and the antifungal medicine cures you of your bad breath then that's really great! If you take antifungal medication and you are not cured of your bad breath, then chances are your bad breath was not caused by Candida. But at least it's one more thing you can cross off your list! And the more things that are crossed off your list, the more time you can spend on finding the cause!
Wow, there's a lot of interest in this topic I can tell. Let me try and cover everyone's questions and concerns in one post.
1.) Yes, here in Thailand itraconazole is available over the counter, as well as ketoconazole. While voriconazole is available here in Thailand, I haven't seen it in any of the pharmacies I've been to. Perhaps they only stock it in the hospitals, or maybe I just haven't noticed it in the pharmacies because I haven't been looking for it. Voriconazole is a hard core anti-fungal, and I believe if you are going to take that one, you really need to be under the care of a doctor. It is for like people who are seriously immunocompromised (i.e. Aids or cancer patients). In regards to posaconazole I have never heard about that one and I don't think it's here in Thailand yet.
2.) I totally agree that everyone should be searching for a doctor who specializes in Fungal infections. Unfortunately, there don't seem to be that many, and the ones who are might be located far away from the patient. I think there have been enough people on this forum whose doctor has dismissed them or looked at them like they were crazy when they mentioned Candida. But that doesn't mean you should give up hope. I have always promoted that people be tested for Candida if they can find a doctor who is willing.
3.) I don't know about meowkity. Perhaps the clotrimazole lotion she rubbed on her chest and neck cleared her tongue, and perhaps it didn't. The odds of that working are very low though. Clotrimazole is rarely absorbed into the bloodstream. If you see the skin chart below while you read this, it will make sense. Basically, the quote below is saying that clotrimazole is only absorbed into the skin in micrograms (mcg), not milligrams (mg). To put it clearly, it would take 1,000 micrograms to equal 1 milligram. You guys are taking 200 milligrams of Fluconazole internally. That would equal 200,000 micrograms. You can see for yourselves in the quote below, but there is nowhere near 200,000 micrograms of clotrimazole cream being absorbed into your skin. But if you don't wanna read the quote, you are basically absorbing only 1 microgram of clotrimazole or less. Needless to say, you are far better off taking the Fluconazole capsule rather than the Clotrimazole cream.
http://www.rxlist.com/lotrisone-drug.htm wrote:The following information was obtained using 1% clotrimazole cream and solution formulations. Six hours after the application of radioactive clotrimazole 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of clotrimazole varied from 100 mcg/cm3 in the stratum corneum, to 0.5 to 1 mcg/cm3 in the reticular dermis, and 0.1 mcg/cm3 in the subcutis. No measurable amount of radioactivity ( < 0.001 mcg/mL) was found in the serum within 48 hours after application under occlusive dressing of 0.5 mL of the solution or 0.8 g of the cream. Only 0.5% or less of the applied radioactivity was excreted in the urine.
4.) To Harry_2K, if I recall correctly, you got your Fluconazole from an online pharmacy, correct? I have said many times, you cannot be certain what you order from an online pharmacy is real or not. The United States FDA found that 24 online pharmacies were selling counterfeit drugs. You can see the names of the websites that were selling fake presciptions at http://www.fda.gov/NewsEvents/Newsroom/ ... 108904.htm. Also you can see the video below about it (sorry there is a 15 second commercial for soap before the actual video.)
<embed src='http://cnettv.cnet.com/av/video/cbsnews ... r-dest.swf' FlashVars='linkUrl=http://www.cbsnews.com/video/watch/?id= ... &salign=tl' allowFullScreen='true' width='425' height='324' type='application/x-shockwave-flash' pluginspage='http://www.macromedia.com/go/getflashplayer'></embed>
5.) I'd have to disagree regarding generic brands being inferior to brand name drugs. The reason brand name drugs are so expensive is because the drug companies have to pay for all the marketing they do, not because the drug is better. The companies that make the generic drugs don't have this overhead, so they can sell the drugs at a cheaper cost. There have been many studies that show generic drugs to be just as effective as brand name drugs. I think the reason some drugs are effective for some people while not effective for others is really because not everyone responds exactly the same to the same treatment. Which leads me to.........
6.) I had a Candida infection in my esophagus. That is what caused my bad breath. But before I found that out, I went through all these things to try and cure my bad breath:
- I bought therabreath - (spent money, it did nothing)
- I bought oxyfresh - (spent money, it did nothing)
- I bought breathrx - (spent money, it did nothing)
- I bought special tongue cleaners - (spent money, it did nothing)
- I bought internal breath fresheners and chewed all kinds of gum - (spent money, it did nothing)
- I had all four of my wisdom teeth removed - (insurance covered it, it did nothing)
- I had my tonsils taken out - (insurance covered it, it did nothing)
- I was a vegetarian for 2 months - (no money lost but time wasted, it did nothing)
- I took PPIs (proton pump inhibitors) for GERD/Acid Reflux (insurance covered it, it did nothing)
- I tried charcoal capsules - (spent money, it did nothing)
- I had deep cleanings by my dentist (insurance covered half, I paid the rest, it did nothing)
- I was diagnosed with Candida, I took BioZole (I was cured)
Obviously, not all of you have bad breath caused by a Candida infection. But as you can see, I tried many different things before I found my cure. All of you will probably have to go through the same thing. It's all trail and error. I pray that some of you will be cured by antifungal medicine, because I really do think Candida infection is more common than doctors would have you believe. If you do indeed have a Candida infection and the antifungal medicine cures you of your bad breath then that's really great! If you take antifungal medication and you are not cured of your bad breath, then chances are your bad breath was not caused by Candida. But at least it's one more thing you can cross off your list! And the more things that are crossed off your list, the more time you can spend on finding the cause!
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm
-
Jimi Stein
- Site Admin
- Posts: 2194
- Joined: Thu Jan 01, 2004 8:00 am
- Gender:
- Contact:
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm
keeptrying, you dont have any idea how much cream I put on, I was probably only supposed to go through like 2 or 3 tubes, and I went through six or 7, the raash itched and I was desperate to get it off. I was constantly running to walgreens before and after they gave me prescription
And quit saying thaat it cannot absorb through the skin, because it can.
And for anyones info, once i realized that it was helping I started applying a very thin layer over my nose.
And Jimi the site didnt cure me, I stumbled on this on my own, but I am very thankful for your site.
I was put on diflucan i pill a week for 4 weeks. I have 1 pill to go.
And quit saying thaat it cannot absorb through the skin, because it can.
And for anyones info, once i realized that it was helping I started applying a very thin layer over my nose.
And Jimi the site didnt cure me, I stumbled on this on my own, but I am very thankful for your site.
I was put on diflucan i pill a week for 4 weeks. I have 1 pill to go.
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm
-
Archimonde
- Super Angel
- Posts: 878
- Joined: Tue Nov 20, 2007 12:14 pm