ECGC - Possible treatment to reduce biofilm
Posted: Tue Aug 02, 2011 2:27 pm
Green Tea Polyphenols Inhibit Candida Biofilm
The formation of Candida albicans into a biofilm is an important requirement for the development of candidiasis. Because green tea polyphenols have been shown to exert both antimicrobial and strong cancer-preventive properties, researchers decided to evaluate their effect on candida biofilm. Cultures treated with 1.0 micromol/l of epigallocatechin-3-gallate (eGCG), the most abundant polyphenol of green tea, displayed a 75% reduction of viable cells during candida biofilm formation. What was really incredible was that established biofilms treated with eGCG were reduced by 80%. Identical concentrations of other green tea polyphenols (e.g., epigallocatechin and epicatechin-3-gallate) demonstrated similar biofilm inhibition. additional investigation found the green tea polyphenols disrupt candida metabolism and structural components.
The significance of this study is extreme as it opens up the possibility that green tea extract may become an important adjunct to treatment of health conditions associated with biofilm formation including chronic candidiasis.
Got this from Consumer Labs
The formation of Candida albicans into a biofilm is an important requirement for the development of candidiasis. Because green tea polyphenols have been shown to exert both antimicrobial and strong cancer-preventive properties, researchers decided to evaluate their effect on candida biofilm. Cultures treated with 1.0 micromol/l of epigallocatechin-3-gallate (eGCG), the most abundant polyphenol of green tea, displayed a 75% reduction of viable cells during candida biofilm formation. What was really incredible was that established biofilms treated with eGCG were reduced by 80%. Identical concentrations of other green tea polyphenols (e.g., epigallocatechin and epicatechin-3-gallate) demonstrated similar biofilm inhibition. additional investigation found the green tea polyphenols disrupt candida metabolism and structural components.
The significance of this study is extreme as it opens up the possibility that green tea extract may become an important adjunct to treatment of health conditions associated with biofilm formation including chronic candidiasis.
Got this from Consumer Labs